SHARE ON: |
| |
| |
 |
 |
|
|
A Canadian biotech company played a key role in developing one of the world’s most promising vaccine candidates that could be days away from seeking emergency approval in the U.S.
Pfizer announced Wednesday that its vaccine, previously believed to be 90 per cent effective, now appears to be 95 per cent effective following more interim results. The company is preparing to formally ask the U.S. Food and Drug Administration to approve emergency use of the vaccine in the coming days.
Vancouver-based biotech company Acuitas Therapeutics contributed to the vaccine candidate by providing an important delivery technology that carries a critical but fragile part of the vaccine into human cells.
Pfizer’s vaccine uses a new approach called messenger RNA technology, which acts like a set of instructions for human cells. Essentially, a vaccine using messenger RNA technology can give directions to cells to make new proteins to help fight off a virus.
The challenge with messenger RNA technology is that it is delicate and can be broken down by the body. So Acuitas Therapeutics developed lipid nanoparticles that act as vehicles for the vaccine to help it get where it needs to be, according to Acuitas Therapeutics CEO and president Thomas Madden.
“The messenger RNA is very fragile after it’s been administered, it’s broken down very quickly in the body, and it also can’t get into our cells where it needs to be to work,” Madden told CTV’s Your Morning on Wednesday. “So we provide a delivery technology that protects the messenger RNA after it’s administered and carries it into the cells and then releases it in the cells so that it can work.”
Pfizer’s vaccine candidate, if approved, could be challenging to distribute because it needs to be stored at -75 C. Madden said this temperature condition was the most cautious approach vaccine developers could take, but further studies may identify a more convenient storage temperature.
“We don’t have the ability to do long stability studies to establish a shelf life for the vaccine at a more convenient temperature,” he said, emphasizing the importance of getting the vaccine approved quickly.
Pfizer’s update comes two days after Moderna announced that its vaccine candidate appears to be 94.5 per cent effective, according to early but incomplete analysis.
The federal government has signed deals with multiple companies, including Pfizer and Moderna, for tens of millions of doses. The approach was meant to ensure that as many Canadians as possible have access to the first vaccine once it’s available.
But before a vaccine can reach the public, it will need to be vetted by health regulators. Infectious diseases specialist Dr. Isaac Bogoch said he wouldn’t be surprised if the first vaccine roll-out programs begin in Canada sometime between January and March of 2021.
“Obviously fingers tightly crossed that it means we can see it here sooner,” he told CTV’s Your Morning.
“It still has to go through the regulatory procedure here in Canada, which means Health Canada is going to have to evaluate all the data and really look at the side effect profile, the safety profile, the efficacy profile, and really determine if this is acceptable or not.”
Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, called vaccine effectiveness above 90 per cent “just extraordinary” and expressed optimism that the U.S. could launch its own vaccine programs before the end of 2020 if a vaccine candidate receives emergency approval.
Bogoch said it’s important to understand the difference between the normal vaccine approval process and the fast-tracked process used in public health emergencies.
“So if you do have an urgent situation such as this, you can have this rapid approval process that’s not technically a full approval process,” he explained. “(It) really says, you know what, we’re still going to do the full look, we’re still going to do the full approach to ensure that this is a safe and effective product. But for now we’re going to do — I wouldn’t say a cursory look, but it’s not a complete look.”
Pfizer studied a group of 44,000 volunteers by giving some the vaccine candidate and others dummy shots. So far 170 volunteers have been infected, and only eight volunteers who received the vaccine contracted COVID-19. Of those, one suffered serious effects of the disease.
The company estimates that it could have 50 million doses ready by the end of 2020, which would provide the necessary two shots for 25 million people. Pfizer could make up to 1.3 billion doses in 2021, enough for roughly 8 per cent of the world’s population.
Acuitas Therapeutics is a relatively small biotech company with 25 employees working out of a building at the University of British Columbia. Formed in 2009, the company specializes in creating delivery systems for nucleic acid therapeutics based on lipid nanoparticles.
|
 |
|
 |
|
 |
|
 |
1 pm |
| 22 ℃ |
| OVERCAST CLOUDS |
WIND: ESE 32 KM/H
GUSTING TO 40 KM/H |
|
|
|
2 pm |
| 22 ℃ |
| OVERCAST CLOUDS |
WIND: ESE 27 KM/H
GUSTING TO 42 KM/H |
|
|
 |
3 pm |
| 22 ℃ |
| LIGHT RAIN |
WIND: ESE 27 KM/H
GUSTING TO 43 KM/H |
|
|
|
4 pm |
| 21 ℃ |
| LIGHT RAIN |
WIND: ESE 27 KM/H
GUSTING TO 42 KM/H |
|
|
|
5 pm |
| 21 ℃ |
| OVERCAST CLOUDS |
WIND: ESE 25 KM/H
GUSTING TO 41 KM/H |
|
|
|
6 pm |
| 20 ℃ |
| OVERCAST CLOUDS |
WIND: ESE 27 KM/H
GUSTING TO 43 KM/H |
|
|
|
7 pm |
| 20 ℃ |
| LIGHT RAIN |
WIND: E 24 KM/H
GUSTING TO 43 KM/H |
|
|
|
8 pm |
| 20 ℃ |
| LIGHT RAIN |
WIND: E 26 KM/H
GUSTING TO 42 KM/H |
|
|
|
|
TODAY |
HIGH OF 22 ℃
LOW OF 14 ℃ |
| VERY HEAVY RAIN |
|
|
|
SUNDAY |
HIGH OF 23 ℃
LOW OF 14 ℃ |
| HEAVY INTENSITY RAIN |
|
|
|
MONDAY |
HIGH OF 23 ℃
LOW OF 12 ℃ |
| MODERATE RAIN |
|
|
|
TUESDAY |
HIGH OF 19 ℃
LOW OF 14 ℃ |
| MODERATE RAIN |
|
|
|
WEDNESDAY |
HIGH OF 21 ℃
LOW OF 13 ℃ |
| BROKEN CLOUDS |
|
|
 |
THURSDAY |
HIGH OF 25 ℃
LOW OF 12 ℃ |
| SCATTERED CLOUDS |
|
|
|
FRIDAY |
HIGH OF 28 ℃
LOW OF 17 ℃ |
| LIGHT RAIN |
|
|
|
SATURDAY |
HIGH OF 27 ℃
LOW OF 19 ℃ |
| LIGHT RAIN |
|
|
|
|
|
|
 |
 |
DALLAS SMITH
TIMELESS
01:06 PM |
|
 |
OLD DOMINION
SLEEP WITHOUT DRINKING
01:02 PM |
|
 |
CASSADEE POPE
SECRET
12:59 PM |
|
 |
SAM GROW
RED LIGHTS
12:56 PM |
|
 |
BILLY CURRINGTON
EVERYTHING IS CHANGING
12:53 PM |
|
 |
KIP MOORE
AROUND YOU
12:49 PM |
|
 |
KANE BROWN
I AM
12:42 PM |
|
 |
ALAN JACKSON
WORK IN PROGRESS
12:38 PM |
|
 |
BRETT YOUNG
KISS TO FORGET
12:36 PM |
|
 |
LILY ROSE
CLIMBING MAGNOLIAS
12:32 PM |
|
 
 |
